If you are designing a scene and the "hot spots" don't align well with the cells, you may need to redesign the card.
If a card printout from L*E*O software needs to be shifted to the right or left or increased or decreased in size, choose Print Adjust...from the File menu and change the settings. Choose Print Preview from the File menu to see how the printout will look before you print it.
If you are editing a Template or Sample Card in Microsoft Word format, you can choose Page Setup...from Word's File menu before printing. For example, make the value for the Left margin slightly smaller to shift the printout to the left; make it larger to shift the printout to the right. Some printer dialogs allow you to specify a percentage to scale the printing of a page.